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KMID : 0882420100780020266
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Korean Journal of Medicine
2010 Volume.78 No. 2 p.266 ~ p.272
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A case of cardiac involvement in Churg-Strauss syndrome presenting without cardiomegaly in an asymptomatic patient
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Kim Su-A
Ahn Hee-Kyung
Lee Su-Jin
Yi Jun-Ho
Jeung Yun-Jin
Lee Byung-Jae
Choi Dong-Chull
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Abstract
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We report a case of Churg-Strauss syndrome with cardiac involvement presenting without cardiomegaly or cardiopulmonary symptoms. A 47-year-old woman was referred to our institution for myalgia, peripheral numbness, and eosinophilia. She had been diagnosed with bronchial asthma and allergic rhinitis four years ago. The patient exhibited eosinophilia (71%) and elevated cardiac enzymes (cTnI, 2.977 ng/mL). Cardiomegaly was not observed on chest radiography, but nonspecific ST segment changes were observed on electrocardiography. A transthoracic echocardiography revealed a dilated left ventricular cavity, a decreased left ventricle (42%), and diastolic dysfunction. Contrast-enhanced cardiac magnetic resonance imaging revealed delayed hyperenhancement 10 minutes after injecting gadolinium. An endomyocardial biopsy showed eosinophilic myocarditis associated with vasculitis. The patient was diagnosed with Churg-Strauss syndrome and received combination therapy with steroid and cyclophosphamide. After the second treatment cycle, the blood eosinophilia disappeared and the vasculitis and infiltration of eosinophils into the endomyocardial tissue had completely resolved.
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KEYWORD
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Churg-Strauss syndrome, Endomyocardial biopsy, Eosinophilic myocarditis
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